The Health Edge: Nutrigenomics


In this episode of The Health Edge Mark and John discuss common single nucleotide polymorphisms (SNPs) commonly found on consumer-based gene analyses like 23 and Me. They discuss the implications for lifestyle, nutritional, and thoughtful supplementation interventions.

Terrific review of Nutrigenomics by Rhonda Patrick PhD

Found MY Fitness- Rhonda Patrick PhD

The Health Edge: Is Alzheimer’s Preventable and Reversible?


In this episode of The Health Edge Mark and John discuss the metabolic disruptors that increase the risk of Alzheimer’s and other “brain-related diseases”. The explore lifestyle interventions proven to restore many of these risk factors. Might Alzheimer’s be preventable or reversible? The research is suggesting a very surprising answer!

B-OH Butyrate and NLRP3 Inflammasome

Health Benefits of Nutritional Ketosis

Nutritional Mental Health 2015

PowerPoint on Core Imbalances Influencing Mind and Mood

MMF metabolic Tune Up

Neuropeptides and microbiota

Bredesen-reversing Alzheimers

The Health Edge: Protein, IGF-1 and Health


In this episode of The Health Edge Mark and John discuss protein intake, sources, and health. They touch on:

  • How much protein is sufficient for most
  • What are the differences between plant and animal protein sources
  • What are the benefits and risks of IGF-1 from a health perspective

Insulin, IGF-1 and Cancer

Red Meat CVD Meta 2010

Meat consumption and mortality – results from the European Prospective Investigation into Cancer and Nutrition

Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men

Insulin-Like Growth Factor I, IGF-Binding Protein 3, and Lung Cancer Risk in a Prospective Study of Men in China

Meta-Analysis and Dose-Response Metaregression- Circulating Insulin-Like Growth Factor I (IGF-I) and Mortality

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

Human conditions of insulin-like growth factor-I (IGF-I) deficiencyIGF-1 promotes the development and cytotoxic activity of human NK cellsInsulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk- pooled individual data analysis of 17

prospective studiesDemonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineInsulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults